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CYCLOTOPE PRODUCTS PEOPLE FACILITIES RESEARCH CYCLOTRON

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GLUCOTOPE(FDG), a glucose analog labeled with fluorine-18, is the most commonly used radiopharmaceutical in PET imaging. It concentrates in cells that rely upon glucose as an energy source or in cells whose dependence on glucose increases under pathophysiological conditions. It has a half-life of 109.7 minutes.

Clinical indications calling for the use of FDG injection and PET imaging include assessment of abnormal glucose metabolism to assist in:

--the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities or in patients with an existing diagnosis of cancer

--the identification of left ventricular myocardium with residual glucose metabolism and reversible loss of systolic function and

--the identification of regions of abnormal glucose metabolism associated with the foci of epileptic seizures.

AMMONIA N 13 is rapidly distributed to all organs of the body after intravenous administration.It is indicated for PET imaging of the myocardium under rest or pharmacological stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease. It has a physical half-life of 9.96 minutes.

SODIUM FLUORIDE F 18 is a positron-emitting radiopharmaceutical that is used for diagnostic purposes in conjunction with PET imaging. Sodium Fluoride is indicated in PET imaging to define areas of bone metastasis and altered osteogenic activity. Fluorine F 18 decays with a physical half-life of 109.7 minutes.